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Real-Time Molecular Surveillance in Colorectal Cancer: Lessons from a Challenging Case
Dr. Phuong presents a case of a 61-year-old woman with sigmoid colon cancer who experienced multiple recurrences despite surgery and systemic therapy. Initially treated with adjuvant FOLFOX6, the patient later developed metastatic lymph node involvement, requiring successive lines of chemotherapy and surgical resections.
The integration of circulating tumor DNA (ctDNA) monitoring via K-TRACK in 2023marked a pivotal advancement in disease surveillance. While conventional tests remained normal, ctDNA positivity in April 2024 signaled recurrence, confirmed by PET-CT, enabling timely intervention. Despite ongoing treatment, ctDNA has remained persistently positive, underscoring its role in detecting minimal residual disease and guiding clinical decisions.
Dr. Phuong’s case illustrates the challenges of managing recurrent colorectal cancer and emphasizes the utility of ctDNA as a real-time, non-invasive biomarker that can guide clinical decisions when traditional diagnostics fall short. Her experience invites further discussion on optimizing surveillance and treatment strategies in the era of precision oncology.
